SPINK7 Chicken Polyclonal Antibody
CNY 5,808.00
CNY 300.00
CNY 1,430.00
CNY 9,998.00
CNY 3,080.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB: 1 ug/mL, ICC: 5 ug/mL |
Reactivity | Human, Mouse, Rat |
Host | Chicken |
Clonality | Polyclonal |
Immunogen | ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2. |
Formulation | ECRG2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | ECRG2 Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | serine peptidase inhibitor, Kazal type 7 (putative) |
Database Link | |
Background | ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer. |
Synonyms | ECG2; ECRG2 |
Reference Data |
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