TMEM88 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TMEM88 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TMEM88.
Formulation	TMEM88 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TMEM88 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	transmembrane protein 88
Database Link	NP_981956 Entrez Gene 67020 MouseEntrez Gene 497936 RatEntrez Gene 92162 Human UniProt ID Q6PEY1
Background	TMEM88 Antibody: Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.
Synonyms	FLJ20025; MGC71744
Reference Data
Protein Families	Transmembrane

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