CMPK2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 ug/ml. IF on FFPE tissues: 20 ug/ml. All other applications and species have not yet been tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CMPK2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human CMPK2.
Formulation	CMPK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CMPK2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	49 kDa
Gene Name	cytidine/uridine monophosphate kinase 2
Database Link	NP_997198 Entrez Gene 22169 MouseEntrez Gene 314004 RatEntrez Gene 129607 Human UniProt ID Q5EBM0
Background	CMPK2 Antibody: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response
Synonyms	NDK; TMPK2; TYKi; UMP-CMPK2
Reference Data
Protein Pathways	Metabolic pathways, Pyrimidine metabolism

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