Prickle 2 (PRICKLE2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PRICKLE2 antibody was raised against a 15 amino acid synthetic peptide near the center of human PRICKLE2.
Formulation	PRICKLE2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PRICKLE2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	prickle planar cell polarity protein 2
Database Link	NP_942559 Entrez Gene 243548 MouseEntrez Gene 312563 RatEntrez Gene 166336 Human UniProt ID Q7Z3G6
Background	PRICKLE2 Antibody: PRICKLE2, also known as Pk2 or EPM5, is a member of a highly conserved protein family that function in the noncanonical WNT signaling pathway which regulates intracellular calcium release and planar cell polarity. Both PRICKLE2 and the related protein PRICKLE1 are expressed in postmitotic neurons and promote neurite outgrowth, and both proteins promote neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. PRICKLE2 localizes to the postsynaptic density and interacts with PSD-95 and NMDA receptors. Defects in the gene encoding PRICKLE2 are associated with autosomal recessive progressive myoclonic epilepsy.
Synonyms	EPM5
Reference Data
Protein Pathways	Wnt signaling pathway

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