NALP6 (NLRP6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	NALP6 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NALP6. The immunogen is located within amino acids 150 - 200 of NALP6.
Formulation	NALP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	NALP6 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NLR family, pyrin domain containing 6
Database Link	NP_612202 Entrez Gene 171389 Human UniProt ID P59044
Background	NALP6 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-κB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
Synonyms	AVR; CLR11.4; NALP6; NAVR; PAN3; PYPAF5
Reference Data

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