NLRC3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3.
Formulation	NOD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	NOD3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NLR family, CARD domain containing 3
Database Link	NP_849172 Entrez Gene 268857 MouseEntrez Gene 287070 RatEntrez Gene 197358 Human UniProt ID Q7RTR2
Background	NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
Synonyms	CLR16.2; NOD3
Reference Data
Protein Families	Druggable Genome

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