Periostin (POSTN) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1-3ug/ml, ELISA: 1:16,000
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-RKLQANKKVQGSRR, from the C Terminus of the protein sequence according to NP_006466.2; NP_001129406.1; NP_001129407.1; NP_001129408.1
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	93.3 kDa
Gene Name	periostin
Database Link	NP_006466 Entrez Gene 10631 Human UniProt ID Q15063
Background	Periostin is a disulfide linked 90 kDa, 811 amino acid protein originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta 1(TGF beta 1) and bone morphogenetic protein (BMP2). Periostin mRNA is expressed in the developing mouse embryonic and fetal heart, and that it is localized to the endocardial cushions that ultimately divide the primitive heart tube into a four-chambered heart. Abnormal expression of periostin is also linked to angiogenesis and metastatsis in epithelial tumors.
Synonyms	OSF-2; OSF2; PDLPOSTN; PN
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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