CREB3 Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.3-1ug/ml, ELISA: 1:128,000
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-HHDHTYSLPRET, from the internal region of the protein sequence according to NP_006359.3
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	41.4 kDa
Gene Name	cAMP responsive element binding protein 3
Database Link	NP_006359 Entrez Gene 10488 Human UniProt ID O43889
Background	This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Nov 2009]
Synonyms	LUMAN; LZIP; sLZIP
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Huntington's disease, Melanogenesis, Prostate cancer

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