Vcam1 Mouse Monoclonal Antibody [Clone ID: eBioMR106 (MR106)]

Specifications

Product Data
Clone Name	eBioMR106 (MR106)
Applications	FC
Recommend Dilution	Flow, IHC, IP, WB
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Formulation	Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	vascular cell adhesion molecule 1
Database Link	NP_035823 Entrez Gene 25361 Rat
Background	The eBioMR106 monoclonal antibody reacts with rat CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and further upregulate VCAM-1 upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin α4β7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.
Synonyms	CD106; DKFZp779G2333; INCAM-100; L1CAM; MGC99561
Reference Data

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