FGF8 Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1-3µg/ml
Reactivity	Human, Mouse, Rat, Dog, Pig
Host	Goat
Clonality	Polyclonal
Immunogen	internal region of NP_149355.1; NP_006110.1; NP_149354.1; NP_149353.1 (HTTEQSLRFEFLNYP)
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	fibroblast growth factor 8
Database Link	NP_149353 Entrez Gene 14179 MouseEntrez Gene 29349 RatEntrez Gene 403868 DogEntrez Gene 2253 Human UniProt ID P55075
Background	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq]
Synonyms	AIGF; FGF-8; HBGF-8; HH6; KAL6
Note	This antibody is expected to recognize all reported isoforms (NP_149355.1; NP_006110.1; NP_149354.1; NP_149353.1)
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton

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