Aromatase (CYP19A1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 10-50 Positive control: Human esophagus cancer Predicted cell location: Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 240-255 amino acids of Human Aromatase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58 kDa
Gene Name	cytochrome P450 family 19 subfamily A member 1
Database Link	NP_000094 Entrez Gene 13075 MouseEntrez Gene 25147 RatEntrez Gene 1588 Human UniProt ID P11511
Background	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol; steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis; three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
Synonyms	ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
Reference Data
Protein Families	Druggable Genome, P450
Protein Pathways	Androgen and estrogen metabolism, Metabolic pathways

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