Prealbumin (TTR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse serum IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Secreted
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	16 kDa
Gene Name	transthyretin
Database Link	NP_000362 Entrez Gene 22139 MouseEntrez Gene 24856 RatEntrez Gene 7276 Human UniProt ID P02766
Background	This gene encodes transthyretin; one of the three prealbumins including alpha-1-antitrypsin; transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid; and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition; affecting predominantly peripheral nerve and/or the heart; and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy; euthyroid hyperthyroxinaemia; amyloidotic vitreous opacities; cardiomyopathy; oculoleptomeningeal amyloidosis; meningocerebrovascular amyloidosis; carpal tunnel syndrome; etc.
Synonyms	CTS; CTS1; HEL111; HsT2651; PALB; TBPA
Reference Data
Protein Families	ES Cell Differentiation/IPS, Secreted Protein

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