GNRHR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: 231 cells and mouse testis tissue
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 62-75 amino acids of Human gonadotropin-releasing hormone receptor
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28 kDa
Gene Name	gonadotropin releasing hormone receptor
Database Link	NP_000397 Entrez Gene 14715 MouseEntrez Gene 2798 Human UniProt ID P30968
Background	This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane; G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes; breast; ovary; and prostate. Following binding of gonadotropin-releasing hormone; the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
Synonyms	GNRHR1; GRHR; HH7; LHRHR; LRHR
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	GnRH signaling pathway, Neuroactive ligand-receptor interaction

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