Myelin Protein Zero (MPZ) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human thyroid cancer Predicted cell location: Cell membrane, Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	myelin protein zero
Database Link	NP_000521 Entrez Gene 17528 MouseEntrez Gene 24564 RatEntrez Gene 4359 Human UniProt ID P25189
Background	This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies. The myelin sheath is a multi-layered membrane; unique to the nervous system; that functions as an insulator to greatly increase the velocity of axonal impulse conduction. The P0 glycoprotein; absent in the central nervous system;[1] is a major component of the myelin sheath in peripheral nerves. It comprises a large extracellular N-terminal domain; a single transmembrane (TM) region; and a smaller positively charged intracellular domain.
Synonyms	CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; P0
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)

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