Neuropeptide Y (NPY) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1000-5000 WB positive control: Mouse adrenal gland tissue lysate
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	11 kDa
Gene Name	neuropeptide Y
Database Link	NP_000896 Entrez Gene 24604 RatEntrez Gene 109648 MouseEntrez Gene 4852 Human UniProt ID P01303
Background	This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes; including cortical excitability; stress response; food intake; circadian rhythms; and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase; activate mitogen-activated protein kinase (MAPK); regulate intracellular calcium levels; and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels; higher alcohol consumption; and may be a risk factor for various metabolic and cardiovascular diseases.
Synonyms	PYY4
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Adipocytokine signaling pathway

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