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PAF Receptor (PTAFR) Rabbit Polyclonal Antibody
CAT＃: TA321248S
Anti-PTAFR Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 25-100 Positive control: Human gasrtic cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 1-14 amino acids of Human platelet-activating factor receptor |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | platelet activating factor receptor |
| Database Link | |
| Background | This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation; tumor growth; angiogenesis; metastasis; and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C; D; A2; mitogen-activated protein kinases (MAPKs); and the phosphatidylinositol-calcium second messenger system. Following PAFR activation; cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation; internalization; and down-regulation. Alternative splicing results in multiple transcript variants. |
| Synonyms | PAFR |
| Reference Data | |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
Documents
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