DAP5 (EIF4G2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela, HepG2 and NIH/3T3 cells
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 796-812 amino acids of Human Eukaryotic translation initiation factor 4 gamma 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	103 kDa
Gene Name	eukaryotic translation initiation factor 4 gamma 2
Database Link	NP_001409 Entrez Gene 13690 MouseEntrez Gene 1982 Human UniProt ID P78344
Background	Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F); which is a cap binding protein complex that consists of three subunits: eIF4A; eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G; in addition; contains a binding site for eIF4E at the N-terminus. Unlike eIF4G; which supports cap-dependent and independent translation; this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Synonyms	AAG1; DAP5; NAT1; P97
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Viral myocarditis

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