Frizzled 2 (FZD2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human renal cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 188-190 amino acids of human led family receptor 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	frizzled class receptor 2
Database Link	NP_001457 Entrez Gene 57265 MouseEntrez Gene 64512 RatEntrez Gene 2535 Human UniProt ID Q14332
Background	This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family; member 3A and wingless-type MMTV integration site family; member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
Synonyms	fz-2; Fz2; fzE2; hFz2
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway

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