GFR alpha 3 (GFRA3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-150 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 346-359 amino acids of Human GDNF family receptor alpha 3
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	GDNF family receptor alpha 3
Database Link	NP_001487 Entrez Gene 14587 MouseEntrez Gene 84422 RatEntrez Gene 2676 Human UniProt ID O60609
Background	GDNF family receptor alpha-3 is a protein that in humans is encoded by the GFRA3 gene. The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand; artemin. Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system; but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues; particularly those of the digestive and urogenital systems; but high expression in stomach and appendix. Several types of glandular tissues show low expression.
Synonyms	GDNFR3
Reference Data
Protein Families	Druggable Genome

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