CXCR3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 351-364 amino acids of Human chemokine (C-X-C motif) receptor 3
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46 kDa
Gene Name	C-X-C motif chemokine receptor 3
Database Link	NP_001495 Entrez Gene 12766 MouseEntrez Gene 84475 RatEntrez Gene 2833 Human UniProt ID P49682
Background	This gene encodes a G protein-coupled receptor with selectivity for three chemokines; termed CXCL9/Mig (monokine induced by interferon-g); CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic; most notably integrin activation; cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine; CXCL4/PF4.
Synonyms	CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R; Mig-R; MigR
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction

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