Inhibin beta A (INHBA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1000-2000 WB positive control: Mouse fat tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 375-390 amino acids of Human Inhibin beta A chain
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	47 kDa
Gene Name	inhibin beta A subunit
Database Link	NP_002183 Entrez Gene 16323 MouseEntrez Gene 29200 RatEntrez Gene 3624 Human UniProt ID P08476
Background	The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition; serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion; it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore; the beta A subunit forms a homodimer; activin A; and also joins with a beta B subunit to form a heterodimer; activin AB; both of which stimulate FSH secretion. Finally; it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Synonyms	EDF; FRP
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

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