PIWIL2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 107-120 amino acids of human piwi-like 2 (Drosophila)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	piwi like RNA-mediated gene silencing 2
Database Link	NP_060538 Entrez Gene 55124 Human UniProt ID Q8TC59
Background	PIWIL2 belongs to the Argonaute family of proteins; which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization; which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes; germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Indirectly modulate expression of genes such as PDGFRB; SLC2A1; ITGA6; GJA7; THY1; CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed; acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors
Synonyms	CT80; HILI; mili; PIWIL1L
Reference Data
Protein Pathways	Dorso-ventral axis formation

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