ENPP6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 10-50 Positive control: Human cervical cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 119-419 amino acids of human ectonucleotide pyrophosphatase/phosphodiesterase 6
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ectonucleotide pyrophosphatase/phosphodiesterase 6
Database Link	NP_699174 Entrez Gene 306460 RatEntrez Gene 320981 MouseEntrez Gene 133121 Human UniProt ID Q6UWR7
Background	Choline-specific glycerophosphodiester phosphodiesterase. Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid; showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C; p-nitrophenyl phosphorylcholine in vitro; while it does not hydrolyze the classical nucleotide phosphodiesterase substrate; p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine; phosphatidylinositol; phosphatidylserine; phosphatidylglycerol and phosphatidic acid.
Synonyms	NPP6
Reference Data
Protein Families	Secreted Protein
Protein Pathways	Ether lipid metabolism

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