CLDN19 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 186-200 amino acids of Human Claudin 19
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23 kDa
Gene Name	claudin 19
Database Link	NP_683763 Entrez Gene 242653 MouseEntrez Gene 298487 RatEntrez Gene 149461 Human UniProt ID Q8N6F1
Background	The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space; through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia; hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars; macular colobomata; significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms	HOMG5
Reference Data
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

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