VANGL2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: NIH/3T3 cells IHC: 15-50 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 20-34 amino acids of human vang-like 2 (van gogh, Drosophila)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	VANGL planar cell polarity protein 2
Database Link	NP_065068 Entrez Gene 93840 MouseEntrez Gene 289229 RatEntrez Gene 57216 Human UniProt ID Q9ULK5
Background	The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity; especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. Plays a role in the regulation of planar cell polarity; particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.
Synonyms	LPP1; LTAP; STB1; STBM; STBM1
Reference Data
Protein Families	Transmembrane
Protein Pathways	Wnt signaling pathway

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