SELS (SELENOS) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm, Endoplasmic reticulum membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 98-112 amino acids of human VCP-interacting membrane protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	VCP interacting membrane selenoprotein
Database Link	NP_060915 Entrez Gene 109815 MouseEntrez Gene 286900 RatEntrez Gene 55829 Human UniProt ID Q9BQE4
Background	This gene encodes a selenoprotein; which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure; the sec insertion sequence (SECIS); that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production; and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms	AD-015; ADO15; SBBI8; SELS; SEPS1
Reference Data
Protein Families	Druggable Genome

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