Calpain 6 (CAPN6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: TM4 and NIH/3T3 cell lysates IHC: 50-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 26-343 amino acids of human calpain 6
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calpain 6
Database Link	NP_055104 Entrez Gene 12338 MouseEntrez Gene 83685 RatEntrez Gene 827 Human UniProt ID Q9Y6Q1
Background	Calpains are ubiquitous; well-conserved family of calcium-dependent; cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain; and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes; as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
Synonyms	CalpM; CANPX; CAPNX; DJ914P14.1
Reference Data
Protein Families	Druggable Genome, Protease

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