MAP3K4 Rabbit Polyclonal Antibody
CAT#: TA322542S
Anti-MAP3K4 Rabbit Polyclonal Antibody
Size: 100 ul
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Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 25-100 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 1282-1286 amino acids of human mitogen-activated protein kinase kinase kinase 4 |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | mitogen-activated protein kinase kinase kinase 4 |
Database Link | |
Background | The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK); which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation; the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock; UV irradiation; wound stress; and inflammatory factors. This gene encodes a MAPKKK; the MEKK4 protein; also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways; but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1; MAPKKs that activate CSBP2 and JNK; respectively but cannot phosphorylate PRKMK1; an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway; and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. |
Synonyms | MAPKKK4; MEKK 4; MEKK4; MTK1; PRO0412 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | GnRH signaling pathway, MAPK signaling pathway |
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