RHEB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 150-162 amino acids of Human Ras homolog enriched in brain
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Ras homolog enriched in brain
Database Link	NP_005605 Entrez Gene 19744 MouseEntrez Gene 26954 RatEntrez Gene 6009 Human UniProt ID Q15382
Background	This gene is a member of the small GTPase superfamily and encodes a lipid-anchored; cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form; and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped; two on chromosome 10 and one on chromosome 22.
Synonyms	RHEB2
Reference Data
Protein Pathways	Insulin signaling pathway, mTOR signaling pathway

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