Deltex (DTX1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 50-64 amino acids of Human deltex homolog 1 (Drosophila)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	deltex 1
Database Link	NP_004407 Entrez Gene 14357 MouseEntrez Gene 1840 Human UniProt ID Q86Y01
Background	Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene. Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however; it may play a role in basic helix-loop-helix transcription factor activity. DTX1 has been shown to interact with EP300. Functions as an ubiquitin ligase protein in vivo; mediating ubiquitination and promoting degradation of MEKK1; suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Synonyms	hDx-1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Notch signaling pathway

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