Securin (PTTG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 100-300 Positive control: Human breast cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 99-112 amino acids of human pituitary tumor-transforming 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	pituitary tumor-transforming 1
Database Link	NP_004210 Entrez Gene 9232 Human UniProt ID O95997
Background	The encoded protein is a homolog of yeast securin proteins; which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo; and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs; which are required for its transforming and tumorigenic activities; as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein; although it partially localizes in the nucleus.
Synonyms	EAP1; HPTTG; PTTG; TUTR1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Cell cycle, Oocyte meiosis

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