alpha Defensin 1 (DEFA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-1000 WB positive control: Human lung tissue IHC: 25-50 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 49-63 amino acids of Human Defensin, alpha 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	10 kDa
Gene Name	defensin alpha 1
Database Link	NP_004075 Entrez Gene 1667 Human UniProt ID P59665
Background	Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine; respiratory tract; urinary tract; and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene; defensin; alpha 1; is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin; alpha 3 by only one amino acid. This gene and the gene encoding defensin; alpha 3 are both subject to copy number variation.
Synonyms	DEF1; DEFA2; HNP-1; HP-1; HP1; MRS
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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