Synaptotagmin V (SYT5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human cerebrum tissue, PC3 cell lysates IHC: 50-200 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 46-200 amino acids of human synaptotagmin V
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	synaptotagmin 5
Database Link	NP_003171 Entrez Gene 53420 MouseEntrez Gene 54309 RatEntrez Gene 6861 Human UniProt ID O00445
Background	Synaptotagmins; such as SYT5; are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C regulatory (C2) domains; which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion; allowing fusion in the presence of calcium; and as calcium receptors or sensor molecules. May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.
Synonyms	synaptotagmin 5; synaptotagmin V
Reference Data
Protein Families	Secreted Protein, Transmembrane

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