MMP3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 350 amino acids of Human Matrix metalloproteinase-3
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	matrix metallopeptidase 3
Database Link	NP_002413 Entrez Gene 4314 Human UniProt ID P08254
Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes; such as embryonic development; reproduction; and tissue remodeling; as well as in disease processes; such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin; laminin; collagens III; IV; IX; and X; and cartilage proteoglycans. The enzyme is thought to be involved in wound repair; progression of atherosclerosis; and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Synonyms	CHDS6; MMP-3; SL-1; STMY; STMY1; STR1
Reference Data
Protein Families	Druggable Genome, Protease

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