DDB1 Rabbit Polyclonal Antibody

CAT#: TA323089

Anti-DDB1 Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ul

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经常一起买 (2)
Transient overexpression lysate of damage-specific DNA binding protein 1, 127kDa (DDB1)
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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 200-1000
WB positive control: MCF-7, Hela and HepG2 cells
IHC: 10-100
Positive control: Human cervical cancer
Predicted cell location: Cytoplasm, Nucleus
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 1125-1140 amino acids of Human DNA damage-binding protein 1
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 127 kDa
Gene Name damage specific DNA binding protein 1
Background The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However; it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition; Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q; but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Synonyms DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
Reference Data
Protein Families Druggable Genome
Protein Pathways Nucleotide excision repair, Ubiquitin mediated proteolysis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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