Collagen II (COL2A1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Rat skeletal muscle tissue lysate IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Secreted
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30 kDa
Gene Name	collagen type II alpha 1 chain
Database Link	NP_001835 Entrez Gene 12824 MouseEntrez Gene 25412 RatEntrez Gene 1280 Human UniProt ID P02458
Background	This gene encodes the alpha-1 chain of type II collagen; a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis; chondrodysplasia; early onset familial osteoarthritis; SED congenita; Langer-Saldino achondrogenesis; Kniest dysplasia; Stickler syndrome type I; and spondyloepimetaphyseal dysplasia Strudwick type. In addition; defects in processing chondrocalcin; a calcium binding protein that is the C-propeptide of this collagen molecule; are also associated with chondrodysplasia. There are two transcripts identified for this gene.
Synonyms	ANFH; AOM; COL11A3; SEDC; STL1
Reference Data
Protein Pathways	ECM-receptor interaction, Focal adhesion

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