HDAC2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human ovarian cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 474-488 amino acids of Human histone deacetylase 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	histone deacetylase 2
Database Link	NP_001518 Entrez Gene 15182 MouseEntrez Gene 3066 Human UniProt ID Q92769
Background	This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes; and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A; H2B; H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins; including YY1; a mammalian zinc-finger transcription factor. Thus; it plays an important role in transcriptional regulation; cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
Synonyms	HD2; RPD3; YAF1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer

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