CELSR2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 2623-2639 amino acids of human cadherin, EGF LAG seven-pass G-type receptor 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cadherin EGF LAG seven-pass G-type receptor 2
Database Link	NP_001399 Entrez Gene 53883 MouseEntrez Gene 83465 RatEntrez Gene 1952 Human UniProt ID Q9HCU4
Background	The protein encoded by this gene is a member of the flamingo subfamily; part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains; seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains; a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication; with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
Synonyms	ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3
Reference Data
Protein Families	Druggable Genome, Transmembrane

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