CDK3 Rabbit Polyclonal Antibody

CAT#: TA323198S

Anti-CDK3 Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

Product images

经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Transient overexpression lysate of cyclin-dependent kinase 3 (CDK3)
    • 100 ug

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Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 25-100
Positive control: Human lung cancer
Predicted cell location: Cytoplasm
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 235-250 amino acids of Human cyclin-dependent kinase 3
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name cyclin-dependent kinase 3
Background This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase; in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1; ATF1; RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities; and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1; E2F2 and E2F3 in a RB1-independent manner.
Synonyms cyclin-dependent kinase 3
Reference Data
Protein Families Druggable Genome, Protein Kinase
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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