Adrenomedullin (ADM) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Secreted
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 129-141 amino acids of human adrenomedullin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	adrenomedullin
Database Link	NP_001115 Entrez Gene 133 Human UniProt ID P35318
Background	Adrenomedullin; a hypotensive peptide found in human pheochromocytoma; consists of 52 amino acids; has 1 intramolecular disulfide bond; and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor; called preproadrenomedullin; is 185 amino acids long. By RNA-blot analysis; human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns; with the 5-prime flanking region containing TATA; CAAT; and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.
Synonyms	AM; PAMP
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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