NFkB p100 / p52 (NFKB2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: U251, MCF-7, HT-29 cell lysates IHC: 50-200 Positive control: Human gastric cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 865-880 amino acids of human nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	97 kDa
Gene Name	nuclear factor kappa B subunit 2
Database Link	NP_001070962 Entrez Gene 18034 MouseEntrez Gene 4791 Human UniProt ID Q00653
Background	This gene encodes one of the subunits of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB transcription factor complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The NFkB complex can consist of different subunits that form both homo- or heterodimers which bind specific kappa-B elements in target genes. This gene encodes the p100 subunit that is processed into the active p52 subunit. This protein can function as both a transcriptional activator and repressor; depending on its dimer partner. Alternate splicing results in both coding and non-coding variants.?
Synonyms	CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p52; p100
Reference Data
Protein Families	Transcription Factors
Protein Pathways	MAPK signaling pathway, Pathways in cancer

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