VMA21 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	IHC: 150-500 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm IF: 50-200 Positive control: HepG2 and NCCIT cell Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 3-16 amino acids of human VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
Database Link	NP_001017980 Entrez Gene 67048 MouseEntrez Gene 203547 Human UniProt ID Q3ZAQ7
Background	This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase. Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. Associates with the V0 complex of the vacuolar ATPase (V-ATPase). MEAX is a childhood-onset disease characterized by progressive vacuolation and atrophy of skeletal muscle. It is inherited in recessive fashion; affecting boys and sparing carrier females. Onset is in childhood; and patients exhibit weakness of the proximal muscles of the lower extremities; progressing slowly to involve other skeletal muscle groups over time.
Synonyms	MEAX; XMEA
Reference Data
Protein Families	Transmembrane

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