CAPNS1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Mouse spleen tissue, K562 and NIH/3T3 cells IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 91-268 amino acids of human calpain, small subunit 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28 kDa
Gene Name	calpain small subunit 1
Database Link	NP_001003962 Entrez Gene 12336 MouseEntrez Gene 29156 RatEntrez Gene 826 Human UniProt ID P04632
Background	Calpains are a ubiquitous; well-conserved family of calcium-dependent; cysteine proteases. Calpain families have been implicated in neurodegenerative processes; as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits; all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.
Synonyms	CALPAIN4; CANP; CANPS; CAPN4; CDPS; CSS1
Reference Data
Protein Families	Druggable Genome, Protease

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