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Apolipoprotein B (APOB) Rabbit Polyclonal Antibody
CAT＃: TA323678S
Anti-APOB Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 15-50 Positive control: Human colon cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 2158-2177 amino acids of human apolipoprotein B (including Ag(x) antigen) |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | apolipoprotein B |
| Database Link | |
| Background | This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms; apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single; very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA); resulting in the creation of a stop codon; and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia; normotriglyceridemic hypobetalipoproteinemia; and hypercholesterolemia due to ligand-defective apoB; diseases affecting plasma cholesterol and apoB levels. |
| Synonyms | FLDB; LDLCQ4 |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
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