Factor VII (F7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: NIH/3T3, 293T and Jurkat cells IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 250 amino acids of human coagulation factor VII (serum prothrombin conversion accelerator)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	49 kDa
Gene Name	coagulation factor VII
Database Link	NP_000122 Entrez Gene 14068 MouseEntrez Gene 2155 Human UniProt ID P08709
Background	This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form; and is converted to an active form by either factor IXa; factor Xa; factor XIIa; or thrombin by minor proteolysis. Upon activation of the factor VII; a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated; and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions; the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms	SPCA
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Complement and coagulation cascades

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