Collagen IV (COL4A3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human ovarian cancer Predicted cell location: Secreted, ExtraCellular matrix, ExtraCellular space
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 41-52 amino acids of human collagen, type IV, alpha 3 (Goodpasture antigen)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	collagen type IV alpha 3 chain
Database Link	NP_000082 Entrez Gene 12828 MouseEntrez Gene 1285 Human UniProt ID Q01955
Background	Type IV collagen; the major structural component of basement membranes; is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes; alpha 1 through alpha 6; each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome; autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family; this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Synonyms	alpha-3 polypeptide; alpha 3 (Goodpasture antigen); alpha 3 type IV collagen; alpha3 type IV collagen; collagen; collagen IV; Goodpasture antigen; OTTHUMP00000195044; TUMSTATIN; tumstatin; type IV
Reference Data
Protein Families	Druggable Genome

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