AGXT Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Human fetal liver tissue and hepg2 cells
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 280-294 amino acids of human alanine-glyoxylate aminotransferase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	alanine-glyoxylate aminotransferase
Database Link	NP_000021 Entrez Gene 11611 MouseEntrez Gene 24792 RatEntrez Gene 189 Human UniProt ID P21549
Background	Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes; where it is involved in glyoxylate detoxification. Mutations in this gene; some of which alter subcellular targetting; have been associated with type I primary hyperoxaluria. Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate; and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.
Synonyms	AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alanine, aspartate and glutamate metabolism, Glycine, serine and threonine metabolism, Metabolic pathways

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