GSK3 beta (GSK3B) Rabbit Polyclonal Antibody
CAT#: TA323991
Anti-GSK3B (Phospho-Tyr216) Rabbit Polyclonal Antibody
Size: 25 ul
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CNY 3,800.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 500-2000 WB positive control: A549 and Hela cell lysates IHC: 20-100 Positive control: Human tonsil Predicted cell location: Cytoplasm |
Reactivity | Human, Mouse, Rat |
Modifications | Phospho-specific |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide sequence around phosphorylation site of tyrosine 216 (V-S-Y(p)-I-C) derived from Human GSK3β. |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 47 kDa |
Gene Name | glycogen synthase kinase 3 beta |
Database Link | |
Background | Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. |
Synonyms | glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Alzheimer's disease, Axon guidance, Basal cell carcinoma, B cell receptor signaling pathway, Cell cycle, Chemokine signaling pathway, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Hedgehog signaling pathway, Insulin signaling pathway, Melanogenesis, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, T cell receptor signaling pathway, Wnt signaling pathway |
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