IL17RC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human tosil Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to N terminal 357 amino acids of Human Interleukin-17 receptor C
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 17 receptor C
Database Link	NP_703193 Entrez Gene 84818 Human UniProt ID Q8NAC3
Background	This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA; which is predominantly expressed in hemopoietic cells; and binds with high affinity to only IL-17A; this protein is expressed in nonhemopoietic tissues; and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines; IL-17A and IL-17F; have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene; and it has been proposed that soluble; secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
Synonyms	FLJ95963; FLJ96005; IL17-RL; IL17F receptor; IL17RL; interleukin 17 receptor-like; interleukin 17 receptor C; MGC10763
Reference Data
Protein Families	Druggable Genome, Transmembrane

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