Caspase 2 (CASP2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-2000 WB positive control: Human fetal kidney and lung tissue IHC: 100-300 Positive control: Human urinary bladder Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to N terminal 201 amino acids of Human Caspase-2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	51 kDa
Gene Name	caspase 2
Database Link	NP_001215 Entrez Gene 12366 MouseEntrez Gene 64314 RatEntrez Gene 835 Human UniProt ID P42575
Background	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways; cell cycle maintenance; and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease; Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms	CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57
Reference Data
Protein Families	Druggable Genome, Protease

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